钩吻素甲
钩吻素甲 性质
| 熔点 | 181-183°C |
|---|---|
| 比旋光度 | D20 +13° (c = 1.2 in chloroform) |
| 沸点 | 461.02°C (rough estimate) |
| 密度 | 1.1478 (rough estimate) |
| 折射率 | 1.5700 (estimate) |
| 储存条件 | 2-8°C |
| 溶解度 | 可溶于氯仿（少许）、甲醇（少许） |
| 形态 | 粉末 |
| 酸度系数(pKa) | 7.75 in 80% methylcellosolve |
| 颜色 | 白色 |
| InChIKey | NFYYATWFXNPTRM-ZFBNGESUNA-N |
| SMILES | [C@]12(C(=O)NC3C=CC=CC1=3)[C@]1([H])OC[C@@]3([H])[C@@]([H])(C1)[C@]1(C=C)CN(C)[C@@]3([H])[C@]21[H] |&1:0,10,14,16,19,25,27,r| |
| LogP | 3.080 (est) |
钩吻素甲 用途与合成方法
Gelsemine is an effective agent for treatment of both neuropathic pain and sleep disturbance in partial sciatic nerve ligation (PSNL) mice. Gelsemine (4 mg/kg) exerts analgesic effects on PSNL-induced mechanical allodynia and thermal hyperalgesia. In PSNL mice, Gelsemine (2 and 4 mg/kg) increases the mechanical threshold for 4 h and prolonged the thermal latencies for 3 h. Furthermore, Gelsemine (4 mg/kg, administered at 6:30 AM) increases non-rapid eye movement (non-REM, NREM) sleep, decreases wakefulness, but does not affect rapid eye movement (REM) sleep during the first 3 h in PSNL mice.
Immunohistochemical study shows that PSNL increases c-Fos expression in the neurons of the anterior cingulate cortex, and Gelsemine (4 mg/kg) decreases c-Fos expression by 58%.
药理药效:具有兴奋中枢神经作用，但毒性很大。
安全信息
| 危险品标志 | T+ |
|---|---|
| 危险类别码 | 23/24/25-26/27/28 |
| 安全说明 | 36/37/39-45-28 |
| 危险品运输编号 | UN 1544 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS号 | LX9100000 |
| 危险等级 | 6.1(a) |
| 包装类别 | I |
| 毒害物质数据 | 509-15-9(Hazardous Substances Data) |
钩吻素甲 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-06-05 | HY-N0388 | 钩吻碱 | 509-15-9 | 5mg | 600 |
| 2026-06-05 | HY-N0388 | 钩吻碱 | 509-15-9 | 10mM * 1mLin DMSO | 660 |
