2-Fluorobenzyl cyanide

clear colorless to yellow-brownish liquid

2-Fluorophenylacetonitrile was used in the synthesis of (Z)-2-(2-fluorophenyl)-3-(1H-pyrrol-2-yl)acrylonitrile.

189g o-fluorobenzyl bromide (1 mol) was dissolved in a solution consisting of 500mL of toluene and 500mL of water, 58.8g of sodium cyanide (1.2 mol) was added, stirring to dissolve, and then 7.4g of tetrabutylammonium bromide (0.02 mol) was added to form a reaction system, and the reaction system was heated to 55C and stirred to react for 10 hours, and the thin layer chromatography (TLC) showed that the reaction of raw materials was complete. Thin layer chromatography (TLC) showed that the reaction of raw materials was complete, the reaction system was static layered, the organic layer was dried and concentrated to obtain the crude product, the crude product was obtained by decompression distillation to obtain 115 g of white liquid, i.e., 2-fluorophenylacetonitrile, the yield was 85%.