NNC 05-2090 hydrochloride (intraperitoneal injection) dose-dependently protects against maximal electroshock (MES) in mice with an ED50 values of 73 μmol/kg, and shows ED50 values against tonic and clonic convulsions in DBA/2 mice of 19 and 26 μmol /kg, respectively[1].
NNC 05-2090 hydrochloride (0.01, 0.1 and 0.3 mg/kg; i.p. or i.,t., once) reverses mechanical allodynia in (partial sciatic nerve ligation) PSL model mice[3].
| Animal Model: | Partial sciatic nerve ligation (PSL) mice with mechanical allodynia[2] |
| Dosage: | 0.01, 0.1 and 0.3 mg/kg |
| Administration: | Intraperitoneal injection or intrathecal injection; 0.1 mg/kg, once |
| Result: | Dose-dependently reversed mechanical allodynia in PSL model mice by both intraperitoneal injection and intrathecal injection. |
