| Name | NNC 05-2090 hydrochloride |
| Description | NNC 05-2090 hydrochloride is a betaine/GABA transporter (BGT-1) inhibitor with an IC50 value of 10.6 μM.NNC 05-2090 hydrochloride can be used for the study of epilepsy and neurological disorders. |
| In vitro | NNC05-2090 hydrochloride binds to prazosin and spiperone with IC50 values of 266 nM and 1632 nM, respectively.[1]
NNC05-2090 hydrochloride (0.1-100 μM) inhibits [3H]GABA uptake in rat cortical synaptosomes with an IC50 value of 4.4 μM.[1]
NNC05-2090 hydrochloride (0.1-100 μM) inhibits [3H]GABA uptake in inferior colliculus synaptosomes with an IC50 value of 2.5 μM.[1]
NNC05-2090 hydrochloride inhibits serotonin, norepinephrine, dopamine transporter, and BGT-1 with IC50 values of 5.29, 7.91, 4.08, and 10.6 μM respectively.[1]
NNC05-2090 hydrochloride inhibits GAT-1, GAT-2 and GAT-3 with IC50s of 29.62, 45.29 and 22.51 μM respectively.[1] |
| In vivo | NNC05-2090 hydrochloride (i.p.; PSL mice) dose-dependently protects mice from maximal electric shock (MES) ED50 of 73 μmol/kg and against tonic and clonic convulsions in DBA/2 mice with an ED50 of 19 μmol /kg and 26 μmol/kg.[1]
NNC05-2090 hydrochloride (0.01, 0.1, 0.3 mg/kg; intraperitoneal or intrathecal injection; once) can dose-dependently reverse mechanical allodynia in PSL model mice by both intraperitoneal injection and intrathecal injection.[2] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | Ethanol : < 5.64 mg/mL
DMSO : 50 mg/mL (110.86 mM)
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| Keywords | NNC 05 2090 hydrochloride | NNC 05-2090 Hydrochloride | NNC 052090 hydrochloride |
| Inhibitors Related | Valproic acid sodium salt | DL-Menthol | p-Hydroxybenzaldehyde | β-Alanine | Penicillin G sodium salt | Halothane | Chlorothymol | Piperazine citrate | Riluzole | Gabapentin | Nikethamide | (-)-α-Pinene |
| Related Compound Libraries | Bioactive Compound Library | Inhibitor Library | Bioactive Compounds Library Max | Ion Channel Targeted Library |
United States
