mPEG3-CH2COOH

Product NamemPEG3-CH2COOH
CAS16024-60-5
MFC9H18O6
MW222.24
EINECS
MOL File16024-60-5.mol

Chemical Properties

Boiling point	338.4±27.0 °C(Predicted)
Density	1.127±0.06 g/cm3(Predicted)
storage temp.	Storage temp. 2-8°C
pka	3.39±0.10(Predicted)
form	Liquid
color	Colorless to light yellow
InChI	InChI=1S/C9H18O6/c1-12-2-3-13-4-5-14-6-7-15-8-9(10)11/h2-8H2,1H3,(H,10,11)
InChIKey	BCGLNCAVZDQPGE-UHFFFAOYSA-N
SMILES	C(O)(=O)COCCOCCOCCOC

Usage And Synthesis

Appearance

White or Off-White Solid

Description

m-PEG4-CH2COOH is a PEG linker containing a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media.

Uses

3,6,9,12-Tetraoxatridecanoic acid is a useful research chemical.

Application

mPEG3-CH2COOH can be used to synthesise lipid couplers of oligo-(14-amino-3,6,9,12-tetraoxotetracosanoic acid) (ATTAn) as monodisperse analogues of poly(ethylene glycol) (PEG) derivatives for use in liposomal drug delivery systems^[1]. mPEG3-CH2COOH contains terminal carboxylic acids. The terminal carboxylic acid readily reacts with primary and secondary amines under EDC, DCC, HATU or other amide coupling conditions to form stable amide bonds. mPEG modification increases the water solubility of the resulting compounds.

IC 50

PEGs

References

[1] STEVEN M. ANSELL. Application of Oligo-(14-amino-3,6,9,12-tetraoxatetradecanoic acid) Lipid Conjugates as Steric Barrier Molecules in Liposomal Formulations[J]. Bioconjugate Chemistry Bioconjugate, 1999. DOI:10.1021/bc990005p.