Triethylene Glycol 2-Bromoethyl Methyl Ether

Product NameTriethylene Glycol 2-Bromoethyl Methyl Ether
CAS110429-45-3
MFC9H19BrO4
MW271.15
EINECS
MOL File110429-45-3.mol

Chemical Properties

Boiling point	296.3±25.0 °C(Predicted)
Density	1.256±0.06 g/cm3(Predicted)
refractive index	1.4620 to 1.4660
storage temp.	2-8°C
form	clear liquid
color	White to Yellow to Green
CAS DataBase Reference	110429-45-3

Safety Information

HS Code

2909.19.6000

Usage And Synthesis

Description

m-PEG4-bromide is a PEG linker containing a bromide group. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The hydrophilic PEG spacer increases solubility in aqueous media.

Biological Activity

Triethylene Glycol 2-Bromoethyl Methyl Ether is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs) of trastuzumab (HY-P9907). It was placed distal to the monomethyl auristatin E (MMAE) payload to generate ADCs with altered hydrophilicity, antigen binding and in vitro potency. Tetraethylene glycol monotosylate can also be used as a linker of PROTAC, which can be used for the synthesis of PROTAC.

in vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

target