1-Hydroxypyrene

1-Hydroxypyrene is a pale yellow solid with no distinct odor. It is slightly soluble in water and readily soluble in organic solvents such as ethanol, methanol, dichloromethane, and acetone. It possesses a conjugated polycyclic aromatic hydrocarbon structure and is relatively chemically stable. It can undergo organic reactions such as esterification and oxidation and exhibits typical fluorescent properties.

Found in humane urine after exposure to coal tar and a coal derived product.

1-Hydroxypyrene is suitable for use in following studies:

• To investigate the fast detection and quantification of 1-hydroxypyrene in tissue extracts from Nereis diversicolor exposed to sediment-associated pyrene by a simple fluorometric method.
• To investigate the effects of genetic polymorphisms of the cytochrome P450 1A1 (CYP1A1) and 2E1 (CYP2E1) and glutathione S-transferases mu (GSTM1) and theta (GSTT1) on urinary 1-hydroxypyrene and 2-naphthol levels in aircraft maintenance workers.
• To examine the the PAH exposure of cokery workers in an Estonian oil shale processing plant.

ChEBI: 1-Hydroxypyrene is a member of pyrenes.