WNT AGONIST 1 (CID11210285 盐酸盐)
WNT AGONIST 1 (CID11210285 盐酸盐)
WNT AGONIST 1 (CID11210285 盐酸盐) 性质
| 沸点 | 623.4±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.353±0.06 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | 在DMSO中的溶解度为20mg/mL，澄清 |
| 形态 | 淡黄色粘稠固体 |
| 酸度系数(pKa) | 6.62±0.10(Predicted) |
| 颜色 | 白色至米色 |
| InChI | 1S/C19H18N4O3/c1-24-14-4-2-3-13(8-14)15-9-18(23-19(20)22-15)21-10-12-5-6-16-17(7-12)26-11-25-16/h2-9H,10-11H2,1H3,(H3,20,21,22,23) |
| InChIKey | FABQUVYDAXWUQP-UHFFFAOYSA-N |
| SMILES | N(Cc3cc4c(cc3)OCO4)c1nc(nc(c1)c2cc(ccc2)OC)N |
WNT AGONIST 1 (CID11210285 盐酸盐) 用途与合成方法
EC50: 700 nM (TCF-dependent transcriptional activity)
BML-284 (10 µM; 24 hours) significantly increases the migration and invasion of both MNK45 and AGS cells and partially restores the migratory and invasive abilities of cells inhibited by pizotifen.BML-284 (10 µM; 24 hours) induces the expression of β-catenin significantly when compared with the NC group. It also partially reverses the effects induced by pizotifen on E-cadherin and N-cadherin expression in MNK45 and AGS cells compared with the pizotifen-treated group.
Western Blot Analysis
| Cell Line: | Human gastric cancer cell lines MNK45 and AGS [1] |
| Concentration: | 10 µM |
| Incubation Time: | 24 hours |
| Result: | Induced β-catenin expression and reserved E-cadherin and N-cadherin expression in MNK45 and AGS cells. |
BML-284 (10 ng) combines with Pyrimethanil (4 mg/L) could partially rescue the malformed phenotype and cardiac defects induced by Pyrimethanil in Tg (myl7:EGFP) transgenic embryos at 5.5 hpf are transferred into plates with 20 embryos.
WNT AGONIST 1 (CID11210285 盐酸盐) 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025-12-22 | HY-19987 | WNT AGONIST 1 (CID11210285 盐酸盐) | 853220-52-7 | 5mg | 660 |
| 2025-12-22 | HY-19987 | WNT AGONIST 1 (CID11210285 盐酸盐) | 853220-52-7 | 10mM * 1mLin DMSO | 726 |
