2-Oleoylglycerol (20 μg/mouse in 0.2 mL PBS, i.v., three times a week for 6 weeks) induces liver fibrosis in a non-alcoholic steatohepatitis (NASH) model through promoting TGF-β1 production in liver MΦs[3].
| Animal Model: | C57BL/6 J mice, CL-HFS-induced non-alcoholic steatohepatitis (NASH) model[3] |
| Dosage: | 20μg/mouse in 0.2mL PBS |
| Administration: | Intravenous administration (I.V.), three times a week for 6 weeks |
| Result: | Showed increased hepatic infiltration of inflammatory cells, increased collagen and α-SMA production; 2-OG enhanced liver resident MΦ and HSC activation. |
