13,14-dihydro-15-keto Prostaglandin D2-d4

13,14-dihydro-15-keto Prostaglandin D2-d4 (13,14-dihydro-15-keto PGD2-d4) is intended for use as an internal standard for the quantification of 13,14-dihydro-15-keto PGD2 (Item No. 12610) by GC- or LC-mass spectrometry. 13,14-dihydro-15-keto PGD2 is a metabolite of PGD2 which is formed through the 15-hydroxy PGDH pathway. 13,14-dihydro-15-keto PGD2 was recently identified as a selective agonist for the CRTH2/DP2 receptor.1 It also inhibits ion flux in a canine colonic mucosa preparation.2 In humans, 13,14-dihydro-15-keto PGD2 is further metabolized to give 11β-hydroxy compounds which have also undergone β-oxidation of one or both side chains. Virtually no 13,14-dihydro-15-keto PGD2 survives intact in the urine.3,4WARNING This product is not for human or veterinary use.

[1] P K RANGACHARI  P A B. Biological activity of metabolites of PGD2 on canine proximal colon.[J]. American Journal of Physiology, 1993, 264 5 Pt 1: G886-94. DOI: 10.1152/ajpgi.1993.264.5.g886
[2] H. HIRAI. Prostaglandin D2 Selectively Induces Chemotaxis in T Helper Type 2 Cells, Eosinophils, and Basophils via Seven-Transmembrane Receptor Crth2[J]. The Tokushima journal of experimental medicine, 2001, 1 1: 255-262. DOI: 10.1084/jem.193.2.255
[3] T E LISTON  L J R. Metabolic fate of radiolabeled prostaglandin D2 in a normal human male volunteer.[J]. The Journal of Biological Chemistry, 1985, 260 24: 13172-13180.
[4] JASON D. MORROW. Quantification of the major urinary metabolite of prostaglandin D2 by a stable isotope dilution mass spectrometric assay[J]. Analytical biochemistry, 1991, 193 1: Pages 142-148. DOI: 10.1016/0003-2697(91)90054-w