13,14-dihydro-15-keto Prostaglandin F2α-d4

13,14-dihydro-15-keto Prostaglandin F_2α-d₄ (13,14-dihydro-15-keto PGF_2α-d₄) contains four deuterium atoms at the 3, 3'', 4, and 4'' positions. It is intended for use as an internal standard for the quantification of 13,14-dihydro-15-keto PGF_2α by GC- or LC-mass spectrometry. 13,14-dihydro-15-keto PGF_2α is the first prominent plasma metabolite of PGF_2α in the 15-hydroxy PGDH pathway. Measurement of 13,14-dihydro-15-keto PGF_2α in plasma can be used as a marker of the in vivo production of PGF_2α.

13,14-Dihydro-15-keto Prostaglandin F2α-d4 (13,14-Dihydro-15-keto-PGF2α-d4) is a deuterated labeled 13,14-Dihydro-15-keto Prostaglandin F2α (HY-113208). 13,14-Dihydro-15-keto Prostaglandin F2α-d4 is an endogenous metabolite present in Blood that can be used for the research of Pregnancy[1][2].

[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. DOI:10.1177/1060028018797110
[2] E W HORTON, et al. A COMPARISON OF THE BIOLOGICAL ACTIVITIES OF FOUR PROSTAGLANDINS. Br J Pharmacol Chemother DOI:10.1111/j.1476-5381.1963.tb01514.x