1-(2-FLUORO-6-(TRIFLOROMETHYL)BENZYL)UREA

1-(2-FLUORO-6-(TRIFLOROMETHYL)BENZYL)UREA can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development and chemical production processes.

In a 250 ml three-necked flask, 3.4 g of E6, 20 ml of water, 4.23 g of urea, and hydrochloric acid (12 mol / L, 2 ml) were added. After refluxing for 3 hours, the reaction solution was cooled to 4 ?? C with an ice water bath, and filtered to obtain 3.78 g of a white solid ( Yield: 91%).