MK 3207 hydrochloride

MK-3207 (Hydrochloride) is a potent and orally bioavailable CGRP receptor antagonist with IC50 of 0.12 nM and Ki of 0.024 nM, and is highly selective versus human AM1, AM2, CTR, and AMY3.

MK-3207 HCl is a potent CGRP receptor antagonist with IC50 and K_i of 0.12 nM and 0.022 nM, respectively, with high selectivity for human AM1, AM2, CTR, and AMY3. Phase 2.

[1] Salvatore CA, et al. Pharmacological properties of MK-3207, a potent and orally active calcitonin gene-related peptide receptor antagonist. J Pharmacol Exp Ther. 2010 Apr;333(1):152-60. DOI:10.1124/jpet.109.163816