6-[(1E,3E)-1,3-Dimethyl-4-(4-nitrophenyl)-1,3-butadienyl]-4-methoxy-3-methyl-2H-pyran-2-one

Luteoreticulin is a nitrophenyl pyranone with immunosuppresive effects.

Luteoreticulin is a rare nitrophenyl pyranone closely related to aureothin, neoaureothin and its unusual photoisomers SNF4435C and SNF4435D. Metabolites within this class are potent antitumour agents with pronounced immunosuppressive activity, and more recently have been shown to reverse multi-drug resistance. The lack of availability of luteoreliculin has hitherto restricted a more intensive investigation of this interesting metabolite.