dianemycin

Product Namedianemycin
CAS35865-33-9
MFC47H78O14
MW867.11
EINECS
MOL File35865-33-9.mol

Chemical Properties

Boiling point	700.37°C (rough estimate)
Density	1.0559 (rough estimate)
refractive index	1.6130 (estimate)
storage temp.	Store at -20°C
solubility	DMSO: 155 mg/mL (178.75 mM); Water: < 0.1 mg/mL (insoluble)
form	Solid
pka	4.59±0.21(Predicted)
color	White to off-white

Usage And Synthesis

Uses

Dianemycin (Nanchangmycin free acid), a polyether antibiotic produced by Streptomyces nanchangensis NS3226, inhibits gram-positive bacteria[1]. Nanchangmycin is a broad spectrum antiviral active against Zika virus[2].

Biological Activity

Dianemycin (Nanchangmycin free acid) is a polyether antibiotic produced by Streptomyces nanchangensis NS3226, which inhibits Gram-positive bacteria. It is also a broad-spectrum antiviral drug against Zika virus.

in vitro

Dianemycin (Nanchangmycin) can be used as a growth promotant in poultry and to cure coccidiosis in chickens. It is active against drug resistant strains of malaria.

target

Bacteria
Zika virus

References

[1] Liu T, et al. Mechanism of thioesterase-catalyzed chain release in the biosynthesis of the polyether antibiotic Nanchangmycin. Chem Biol. 2008 May;15(5):449-58. DOI:10.1016/j.chembiol.2008.04.006
[2] Rausch K, et al. Screening Bioactives Reveals Nanchangmycin as a Broad Spectrum Antiviral Active against Zika Virus. Cell Rep. 2017 Jan 17;18(3):804-815. DOI:10.1016/j.celrep.2016.12.068