Uses
Dianemycin (Nanchangmycin free acid), a polyether antibiotic produced by Streptomyces nanchangensis NS3226, inhibits gram-positive bacteria[1]. Nanchangmycin is a broad spectrum antiviral active against Zika virus[2].
Biological Activity
Dianemycin (Nanchangmycin free acid) is a polyether antibiotic produced by Streptomyces nanchangensis NS3226, which inhibits Gram-positive bacteria. It is also a broad-spectrum antiviral drug against Zika virus.
in vitro
Dianemycin (Nanchangmycin) can be used as a growth promotant in poultry and to cure coccidiosis in chickens. It is active against drug resistant strains of malaria.
References
[1] Liu T, et al. Mechanism of thioesterase-catalyzed chain release in the biosynthesis of the polyether antibiotic Nanchangmycin. Chem Biol. 2008 May;15(5):449-58. DOI:
10.1016/j.chembiol.2008.04.006[2] Rausch K, et al. Screening Bioactives Reveals Nanchangmycin as a Broad Spectrum Antiviral Active against Zika Virus. Cell Rep. 2017 Jan 17;18(3):804-815. DOI:
10.1016/j.celrep.2016.12.068
