S-TRITYL-3-MERCAPTOPROPIONIC ACID

76-84-6

107-96-0

27144-18-9

General procedure for the synthesis of 3-(triphenylmethylthio)propionic acid from triphenylmethanol and 3-mercaptopropionic acid: 1. 100 g of 3-mercaptopropionic acid (942.15 mmol) was dissolved in 300 mL of glacial acetic acid at room temperature. 2. 245.27 g of triphenylmethanol (942.15 mmol) was dissolved in 736.79 mL of tetrahydrofuran (THF) at room temperature. 3. Slowly add the solution obtained from step 1 to the solution from step 2. 4. 16.62 g of concentrated sulfuric acid (98%, 169.587 mmol) is added slowly and dropwise at 28° C to 30° C. The reaction mixture is insulated. 5. The reaction mixture was stirred under insulating conditions for 4 hours. 6. Upon completion of the reaction, 360 g of solid crude product was obtained by filtration. 7. The crude product was dissolved in 720 mL of N,N-dimethylformamide (DMF). 8. 5 times the volume of water was added to the solution, filtered and dried to give 295.5 g of refined product in 90% yield. 9. The structure of the product was confirmed by infrared spectroscopy (IR) and nuclear magnetic resonance (NMR).