M40 (0.1-1 nmol, intracisternal injection, single dose) blocks selectively the central cardiovascular responses induced by galanin-(1–15) in Sprague-Dawley rats models, according to the recognization of galanin receptor in N-terminus[1].
M40 (2-8 nmol, intraventricular or intrahippocampal, single dose) exhibits antagonist efficacy against galanin on memory tasks in sprague-dawley rats models, exhibits potency in alleviating the cognitive deficits associated with Alzheimer's disease[2].
| Animal Model: | Vasopressor and tachycardia induced by galanin in Sprague-Dawley rats[1] |
| Dosage: | 0.1-1 nmol |
| Administration: | Intracisternal injection, single dose |
| Result: | Blocked the feeding effects of galanin in the hypothalamus and amygdala.
Reduced vasopressor response and heart rate induced by galanin-(1-15), but not those effects induced by galanin-(1-29). |
| Animal Model: | Memory impairment induced by galanin in rats model[2] |
| Dosage: | 2-8 nmol |
| Administration: | intraventricular or intrahippocampal, single dose |
| Result: | Blocked the impairment in choice accuracy. |
