Tubulin-β 1 (TUBB1) interaction with microtubule-associated proteins (MAPs) such as tau is fundamental for microtubule structure and function. It has a role in the formation of the cytoskeleton. Studies revealed th at TUBB1 is the target of various antitubulin agents used in the treatment of cancer. Subsequent studies have also concluded th at TUBB1 mutations in clinical samples are rare, and unlikely to contribute to drug resistance.
