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CYCLOOCTANONE

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CYCLOOCTANONE Basic information
CYCLOOCTANONE Chemical Properties
  • Melting point:32-41 °C (lit.)
  • Boiling point:195-197 °C (lit.)
  • Density 0.958 g/mL at 25 °C (lit.)
  • refractive index 1.4694
  • Flash point:163 °F
  • storage temp. Sealed in dry,Room Temperature
  • solubility 15g/l
  • form Crystalline Low Melting Solid
  • color Colorless to white
  • PH7 (15g/l, H2O, 20℃)
  • Water Solubility Soluble in water at 20°C 15g/L. Soluble in acetone, alcohol, chloroform, methanol and benzene.
  • BRN 1280738
  • InChIKeyIIRFCWANHMSDCG-UHFFFAOYSA-N
  • CAS DataBase Reference502-49-8(CAS DataBase Reference)
  • EPA Substance Registry SystemCyclooctanone (502-49-8)
Safety Information
MSDS
CYCLOOCTANONE Usage And Synthesis
  • Chemical Propertiescolorless to white crystalline low melting solid
  • UsesCyclooctanone is a aliphatic cycle that exhibited inhibitory activity towards aldosterone synthase, a promising therapeutic target for the treatment of cardiovascular diseases related to abnormally high aldosterone level.
  • Synthesis Reference(s)Journal of the American Chemical Society, 92, p. 5276, 1970 DOI: 10.1021/ja00720a078
    The Journal of Organic Chemistry, 49, p. 3912, 1984 DOI: 10.1021/jo00195a007
    Tetrahedron Letters, 36, p. 2921, 1995 DOI: 10.1016/0040-4039(95)00467-Q
  • Purification MethodsPurify the ketone by sublimation after drying with Linde type 13X molecular sieves. The semicarbazone has m 168-169o (from dioxane) [Kohler et al. J Am Chem Soc 61 1060 1939]. The oxime has m 36-37o after subliming at high vacuum or distillation and has b 128-129o /14mm. The iso-oxime has m 72-73o [Ruzicka et al. Helv Chim Acta 32 548 1949]. [Beilstein 7 III 77, 7 IV 49.]
CYCLOOCTANONE Preparation Products And Raw materials
CYCLOOCTANONE(502-49-8)Related Product Information
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