异去氢钩藤碱
异去氢钩藤碱 性质
| 沸点 | 562.7±50.0 °C(Predicted) |
|---|---|
| 密度 | 1.25 |
| 溶解度 | DMSO：50 mg/mL（130.74 mM；需要超声波） |
| 形态 | 粉末 |
| 酸度系数(pKa) | 13.54±0.60(Predicted) |
| 颜色 | 白色至米白色 |
异去氢钩藤碱 用途与合成方法
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5-HT 2A Receptor 72.4 μM (IC 50 ) |
Isocorynoxeine inhibits 5-HT 2A receptor-mediated 5-HT currents. Isocorynoxeine prefer to interact with 5-HT 2A receptors rather than with 5-HT 2C receptors in the brain.Isocorynoxeine exhibits less potent inhibitory activity (with IC 50 values of > 100 μM) against the 5-HT 2C receptor-mediated response than the 5-HT 2A receptor-mediated response in oocytes. Isocorynoxeine dose-dependently and competitively inhibits 5-HT-evoked currents in Xenopus oocytes expressing 5-HT 2A receptors, but has less of a suppressive effect on those in oocytes expressing 5-HT 2C receptors.
The effects of Rhynchophylline, Corynoxeine, and Isocorynoxeine, isorhynchophylline-related alkaloids present are tested in Uncaria species, on 5-MeO-DMT-induced head-twitch behaviour in reserpinized mice. Neither Rhynchophylline [H=1.369, P=0.504] nor Corynoxeine [H=0.242, P=0.886] affects the behaviour, while Isocorynoxeine significantly attenuates it at 30 mg/kg (i.p.) [H=7.582, P<0.01].
异去氢钩藤碱 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-11-08 | HY-N0775 | 异去氢钩藤碱 | 51014-29-0 | 5mg | 1450 |
| 2024-11-08 | HY-N0775 | 10 mM * 1 mLin DMSO | 1595 |
