4-bromopyrene

4-Bromopyrene is an intermediate in the synthesis of Acepyrene (A130950), a novel constituent discovered that belongs to the pyrene class of the polycyclic aromatic hydrocarbons.

Under the protection of nitrogen gas, add pyrene to 500ml clean and dry three-necked flasks in a certain proportion, DMF, stirring until the solid is completely soluble, reduce the temperature to 0-10 , add NBS, hold at 0-10 for 2 h. Take a sample of hydrolysis and TLC tracking until pyrene disappeared; hydrolysis, add ethylene dichloride extraction, wash with water to neutral, desiccation of solvents, chloroform/hexane mixture of solvents over the silica column, toluene recrystallization to obtain 4 -Bromopyrene.