safracin B

Product Namesafracin B
CAS87578-99-2
MFC28H36N4O7
MW540.61
EINECS
MOL File87578-99-2.mol

Chemical Properties

Boiling point	755.1±60.0 °C(Predicted)
Density	1.41±0.1 g/cm3(Predicted)
storage temp.	-20°C
solubility	Soluble in DMSO (up to 20 mg/ml)
form	solid
pka	9.75±0.70(Predicted)
color	Yellow-green
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Usage And Synthesis

Description

Safracin B (87578-99-2) is a novel antibiotic of the saframycin family produced byPseudomonas fluorescens.1Safracin B displays antitumor activity against L1210 and P388 leukemias and B16 melanoma. Compared with safracin A, the toxic and effective doses were much lower. Safracin B also prolonged the life of tumor-bearing mice to a greater extent than safracin A.2

Uses

Safracin B is a new antibiotics from the family of Safracin produced by Pseudomonas fluorescens A2-2. Safracin B is an antibiotic that exhibits anti-tumor properties.

in vivo

Safracin B (0.005-5 mg/kg/day; for 9 days) prolongs the life span of tumor-bearing mice and shows antitumor activity against L1210 and P388 leukemias and B16 melanoma in Female BALB/c x DBA/2 F₁ (CD2F₁) mice weighing 19-24 g^[2].
The LD₅₀ is 7.3 mg/kg with safracin B in normal CD2F₁ mice by ip administration^[2].

References

[1] Y IKEDA. Safracins, new antitumor antibiotics. I. Producing organism, fermentation and isolation.[J]. Journal of Antibiotics, 1983, 36 10: 1279-1283. DOI:10.7164/antibiotics.36.1279
[2] T OKUMOTO. Activity of safracins A and B, heterocyclic quinone antibiotics, on experimental tumors in mice.[J]. Journal of Antibiotics, 1985, 38 6: 767-771. DOI:10.7164/antibiotics.38.767