pKa values after treatment with HCl-methanol: 3.55, 8.10, 9.75(at 25℃)
Safety Information
Toxicity
LD50 i.v. in mice: 400-500 mg/kg (Hameda)
Usage And Synthesis
Uses
Negamycin is a compound with antibacterial activity that inhibits protein synthesis by binding to the head domain of the bacterial ribosomal small subunit, leading to cell death, and also promotes misreading of near-cognate codons.
References
[1] Negamycin induces translational stalling and miscoding by binding to the small subunit head domain of the Escherichia coli ribosome DOI:10.1073/pnas.1414401111
