Karanjin (50, 100 mg/kg, p.o., 6 h) reduces the blood glucose level of Streptozotocin (HY-13753)-induced diabetic rats[1].
Karanjin (20 mg/kg/d, p.o., 21 d) reduces joint injury and cartilage damage along with edema and erythema in the AIA model rats[1].
Karanjin (10, 20 mg/kg/d, p.o., 14 d) significantly decreases serum ACP, ALP and TNFα levels in the AIA model rats [1].
Karanjin (25 or 50 mg/kg/d, p.o. or i.g., 8 d) improved learning and memory in Diazepam-induced amnesia mice[1].
| Animal Model: | Streptozotocin-induced diabetic rats[1] |
| Dosage: | 50, 100 mg/kg |
| Administration: | Oral gavage (p.o.), wait for 6h |
| Result: | Lowered the blood glucose level by 11.7% and 20.7% at 50 and 100 mg/kg gavage. |
| Animal Model: | Adjuvant induced arthritis model (AIA) Wistar strain male albino rats[1] |
| Dosage: | 10, 20 mg/kg/d |
| Administration: | Oral gavage (p.o.), 14 d for serum assay, 21 d for histological examination |
| Result: | Reduced articular cartilage damage, cellular infiltration in the articular cartilage and spongy bone damage significantly. Decreased serum acid phosphatase, alkaline phosphatase levels and TNFα level markedly. |
| Animal Model: | Diazepam-induced male swiss albino mice [1] |
| Dosage: | 25, 50 mg/kg/d |
| Administration: | Oral gavage (p.o.) or Intraperitoneal injection (i.p.) for 8 d |
| Result: | Decreased the transfer latency on all the observation days, significantly reversed diazepam-induced amnesia, indicating improved learning and memory in treated mice. |
