Defibrase,Serono,W. Germany,1982
Defibrase, deinagkistrodonacutus is a proteolytic enzyme extraction of Agkistrodon halys venom. Defibrase can be used for degradation of fibrinogen. Defibrase can exacerbate myosin-induced EAM (experimental autoimmune myositis). Defibrase can be used for degradation of fibrinogen. Defibrase is commonly used for research of acute ischemic cerebrovascular disease, thromboangiitis obliterans, deep phlebitis and sudden deafness[1].
The process for preparing the enzyme composition comprises treating an
aqueous solution of the snake venom at a pH of about 4 to 6 with phenol or a
phenol derivative in order to precipitate an insoluble complex containing the
active venom fraction and decomposing the complex in order to release the
thrombinlike enzyme composition.
[1] Wen-Jing L, et al. A new modified animal model of myosin-induced experimental autoimmune myositis enhanced by defibrase. Arch Med Sci. 2015 Dec 10;11(6):1272-8. DOI:
10.5114/aoms.2015.52883
