哌卡嗪盐酸盐
中文名称:哌卡嗪盐酸盐
英文名称:10-[(1-methyl-3-piperidyl)methyl]-10H-phenothiazine monohydrochloride
CAS号:2975-36-2
分子式:C19H23ClN2S
分子量:346.91732
EINECS号:221-020-8
Mol文件:2975-36-2.mol
哌卡嗪盐酸盐 性质
| 熔点 | 180-181 °C |
|---|---|
| 沸点 | 180-183 °C(Press: 0.5 Torr) |
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：50 mg/ml（144.13 mM） |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
哌卡嗪盐酸盐 用途与合成方法
Mepazine hydrochloride (Pecazine hydrochloride) 是一种有效的选择性 MALT1 蛋白酶抑制剂。Mepazine hydrochloride 抑制全长 GSTMALT1 和 GSTMALT1 325-760 段的IC50 分别为 0.83 和 0.42 μM。Mepazine hydrochloride 通过增强细胞凋亡 (apoptosis) 来影响 ABC-DLBCL 细胞的生存能力。
MALT1
Mepazine (5-20 μM; 4 days) causes a decrease of cell viability in the activated B cell subtype of diffuse large B cell lymphoma (ABCDLBCL) cells, without significantly affecting GCB-DLBCL cells.
Cell Viability Assay
| Cell Line: | ABC-DLBCL cell lines (HBL1, OCI-Ly3, U2932, TMD8, OCI-Ly10) and GCB-DLBCL cell lines (BJAB, Su-DHL-6, Su-DHL-4) |
| Concentration: | 5, 10, and 20 μM |
| Incubation Time: | 4 days |
| Result: | Caused a decrease of cell viability in the ABC-DLBCL cells HBL1, OCI-Ly3, U2932, and TMD8, without significantly affecting GCB-DLBCL cells. |
Mepazine (16 mg/kg; intraperitoneal administration) interferes with growth and induces apoptosis of ABC-DLBCL cell line OCI-Ly10 in NOD/scid IL-2Rg null (NSG) mice with a murine DLBCL xenogeneic tumor model. Daily administration of Mepazine strongly impairs the expansion of the ABC-DLBCL cell line OCI-Ly10.
| Animal Model: | 6- to 8-week-old female NOD.Cg- Prkdc scid Il2rg tm1Wjl /SzJ (NSG) mice with a murine DLBCL xenogeneic tumor model |
| Dosage: | 400 μg per animal (25 g), corresponding to approximately 16 mg/kg |
| Administration: | Intraperitoneal administration; started 1 or 12 days after transplantation and given continuously every 24 hr; daily application |
| Result: | Daily administration strongly impaired the expansion of the ABC-DLBCL cell line OCI-Ly10. |
哌卡嗪盐酸盐 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-11-08 | HY-121282A | 哌卡嗪盐酸盐 | 2975-36-2 | 25 mg | 1150 |
| 2024-11-08 | HY-121282A | 哌卡嗪盐酸盐 | 2975-36-2 | 10mM * 1mLin DMSO | 1270 |
哌卡嗪盐酸盐供应商 更多
常州平博医药研发有限公司
联系电话：0519-83990708
产品介绍：
中文名称：哌卡嗪盐酸盐
英文名称：10-((1-methylpiperidin-3-yl)methyl)-10H-phenothiazine hydrochloride
CAS：2975-36-2
纯度：97%
包装信息：5g,10g,25g,100g,500g,1kg,5kg,25kg,100kg
备注：现货
上海超岚化工科技中心
联系电话：021-QQ：65489617 15618227136
产品介绍：
CAS：2975-36-2
纯度：98%
包装信息：5MG;10MG;50MG;100MG,1G,5G,100G
北京普西唐生物科技有限公司
联系电话：010-60605840 18892239720
产品介绍：
中文名称：甲哌啶嗪盐酸盐
英文名称：Mepazine hydrochloride
CAS：2975-36-2
纯度：98%
包装信息：25mg;50mg;100mg
最新发布供应信息
2975-36-2Mepazine hydrochloride
上海嘉定区澄浏公路52号
2024-11-25
2975-36-2；哌卡嗪盐酸盐
陕西缔都医药化工有限公司
2024-11-25
