Sulforidazine,ZYF Pharm Chemical
Thioridazine 2-Sulfone (Thioridazine EP Impurity E) is a major metabolite of Thioridazine (THD 2-SO2).
ChEBI: Sulforidazine is a member of phenothiazines.
A mixture of 96.5 g 2-methylsulfonylphenothiazine, 50 g 2-(2-chloroethyl)-1-
methylpiperidine, 62 g diethyl carbonate and 2 g sodium methylate was
heated at 135°C for 1 hour and then at 180-190°C for 2.5 hours. The product
was dissolved in benzene (500 ml) and the solution was extracted with 700 ml
of 15% aqueous solution tartaric acid. The extract was washed with benzene.
After addition of sodium carbonate solution to the extract was obtained a
precipitate which was dissolved in benzene. This solution was washed with
water and concentrated. 2-Methylsulfonyl-10-(2-(1-methyl-2-
piperidyl)ethyl)phenothiazin was recrystallized from acetone, melting point
121-123°C.
