Ac-DEVD-CHO is a potent inhibitor of the Group II caspases, caspase-3 and caspase-7 (Kis = 0.23 and 1.6 nM, respectively).1,2 Notably, it also inhibits other caspases (Kis = 18, 1710, 132, 205, 31, 0.92, 60, and 12 nM for caspases-1, -2, -4, -5, -6, -8, -9, and -10, respectively).1 Caspase inhibitors in the aldehyde form, like this compound, are typically reversible, whereas methyl ketone forms, like Ac-DEVD-CMK (Item No. 14465), are irreversible.1 Caspase inhibitors interfere with the initiation of apoptosis and have numerous possible clinical applications.3WARNING This product is not for human or veterinary use.
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10.1074/jbc.273.49.32608[2] R V TALANIAN. Substrate specificities of caspase family proteases.[J]. The Journal of Biological Chemistry, 1997, 272 15: 9677-9682. DOI:
10.1074/jbc.272.15.9677[3] DONALD W. NICHOLSON. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis[J]. Nature, 1995, 376 6535: 37-43. DOI:
10.1038/376037a0[4] HITESH SONI Adebowale A. TRPC6 channel activation promotes neonatal glomerular mesangial cell apoptosis via calcineurin/NFAT and FasL/Fas signaling pathways.[J]. Scientific Reports, 2016: 29041. DOI:
10.1038/srep29041
