cis-1,2-Cyclopentanedicarboxylic Anhydride functions as a reagent in the enantioselective synthesis of disubstituted proline derivatives and its application in synthesis of hepatitis C virus protease inhibitor telaprevir, Nrf2-Keap1 complex inhibitors preparation, binding mode and structural-activity relationship.
In a 250 ml aubergine flask, 2 g of cis-cyclopentyl-1,2dicarboxylic acid and 126.4 ml of acetic anhydride were added, heated and refluxed for 10 h. Excess acetic anhydride was removed under reduced pressure to obtain the crude cyclopentane-1,2-dicarboxylic anhydride.
