2,5-Dichlorothiophene

188290-36-0

3172-52-9

The general procedure for the preparation of 2,5-dichlorothiophene is as follows: 1. 300 g of carbon tetrachloride and 84 g of thiophene were added to a 1000 mL three-necked flask, heated to reflux temperature and then 270 g of N-chlorotoluene diimide was slowly added. 2. After completion of the reaction, the reaction mixture was cooled to room temperature and filtered to remove insoluble impurities. 3. The filtrate was concentrated to recover carbon tetrachloride to give the remaining reaction mixture. 4. 4. the remaining reaction mixture was heated to 100 °C and subjected to reduced pressure distillation. 5. The 100 °C fraction was collected as the target product 2,5-dichlorothiophene in a yield of 145 g, 95% yield and 98.5% purity.