Ramatercept

Ramatercept is a soluble ActRIIB receptor and can be used as a soluble activin receptor 2 (ACVR2) antagonist. Ramatercept inhibits the signal pathway of muscle growth inhibition and has potential application in muscle atrophy.

Ramatercept (ACE-031) is a soluble ActRIIB receptor and can be used as a soluble activin receptor 2 (ACVR2) antagonist. Ramatercept inhibits the signal pathway of muscle growth inhibition and has potential application in muscle atrophy[1][2][3].

Ramatercept (10 mg/kg; s.c.; three times a week for 5 weeks) significantly increases the muscle mass of mice.

[1] Fariello R G, et al. A novel Biological (FOX-115) improves endurance of motor performances in old mice (P2. 4-033)[J]. 2019.
[2] Feike Y, et al. Advances in research on pharmacotherapy of sarcopenia. Aging Med (Milton). 2021 Aug 9;4(3):221-233. DOI:10.1002/agm2.12168
[3] Louvel é. Dopage: nouveaux médicaments influant sur la biogenèse musculaire et mitochondriale[J]. 2019.