Ramatercept is a soluble ActRIIB receptor and can be used as a soluble activin receptor 2 (ACVR2) antagonist. Ramatercept inhibits the signal pathway of muscle growth inhibition and has potential application in muscle atrophy.
in vivo
Ramatercept (10 mg/kg; s.c.; three times a week for 5 weeks) significantly increases the muscle mass of mice.
