ATP synthase inhibitor 1

Product NameATP synthase inhibitor 1
CAS1023043-30-2
MFC17H18ClN3O3S2
MW411.93
EINECS
MOL File1023043-30-2.mol

Chemical Properties

Density	1.55±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C,unstable in solution, ready to use.
solubility	DMSO: 5 mg/mL (12.14 mM)
pka	14.80±0.20(Predicted)
form	Solid
color	Off-white to light yellow

Usage And Synthesis

Description

ATP synthase inhibitor 1 is a potent inhibitor of c subunit of the F1/FO-ATP synthase complex, inhibits mitochondrial permeability transition pore (mPTP) opening, does not affect ATP levels[1]. F1/FO-ATP synthase[1]

ATP synthase inhibitor 1 (Compound 10) is a potent inhibitor of c subunit of the F1/FO-ATP synthase complex[1].

Uses

ATP synthase inhibitor 1 is a potent inhibitor of c subunit of the F1/FO-ATP synthase complex, inhibits mitochondrial permeability transition pore (mPTP) opening, does not affect ATP levels[1].

References

[1]. Morciano G, et al. Discovery of Novel 1,3,8-Triazaspiro[4.5]decane Derivatives That Target the c Subunit of F1/FO-Adenosine Triphosphate (ATP) Synthase for the Treatment of Reperfusion Damage in Myocardial Infarction. J Med Chem. 2018 Aug 23;61(16):7131-7143.