3,6-Diiodopyridazine

141-30-0

20698-04-8

Example 12 Synthesis of compound 12: To 2 g of 3,6-dichloropyridazine was added 60 ml of acetone and 20.12 g (268.4 mmol) of sodium iodide, and the mixture was stirred under reflux conditions (bath temperature: 70 °C) for 2 hours. After completion of the reaction, water was added to the reaction mixture and extracted with ethyl acetate. The organic layer was washed sequentially with saturated aqueous sodium thiosulfate and saturated aqueous sodium chloride, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 2.73 g (8.23 mmol) of 3,6-diiodopyridazine in 61% yield.