OD 36 is a potent and selective inhibitor of RIPK2 (Receptor-Interacting serine/threonine-Protein Kinase 2).
Cell permeable: yes', 'Primary Target
RIPK2
OD36 (6.25 mg/kg; i.p.; once) alleviates inflammation in an acute peritonitis mice model[3].
| Animal Model: | C57BL/6 mice, muramyl dipeptide (MDP)-induced model of peritonitis[3] |
| Dosage: | 6.25 mg/kg |
| Administration: | Intraperitoneal injection, 30 min prior to MDP |
| Result: | Inhibited the recruitment of inflammatory cells to the peritoneum, specifically that of neutrophils, and, to a lesser extent, lymphocytes. Decreased RIPK2-specific genes as well as inflammatory cytokine and chemokine gene expression. |
RIPK2: 5.3 nM (IC50); ACVR1: 37 nM (Kd); ACVR1: 47 nM (IC50); ALK2 R206H: 22 nM (IC50)
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