Yellowliquid. Slightly soluble in water; soluble in most organic
solvents.
Sulfotep is a yellow mobile liquid. Garliclike odor.
An organophosphate pesticide that is an inhibitor of acetylcholinesterase (AChE).
Sulfotep is used to control aphids, thrips, mites and whiteflies in
glasshouses by fumigation. It also used to control sciarid and phorid flies
in mushrooms.
Sulfotep is commercially produced via the thionation of tetraethyl pyrophosphate (itself synthesized by condensation of diethyl phosphorochloridate with sodium diethyl phosphate or hydrolysis of diethyl chlorophosphate followed by esterification) with elemental sulphur in an inert solvent like toluen, yielding the active compound.
ChEBI: Sulfotep is an organic thiophosphate and an organothiophosphate insecticide. It has a role as an EC 3.1.1.7 (acetylcholinesterase) inhibitor, an EC 3.1.1.8 (cholinesterase) inhibitor, an acaricide and an agrochemical. It is functionally related to a dithiodiphosphoric acid.
Tetraethyl dithiopyrophosphate and compressed gas mixture is a liquid charged with a gas. Tetraethyl dithiopyrophosphate is a yellow liquid. Its vapor is heavier than air. SULFOTEP is lethal by skin absorption and inhalation. Prolonged exposure of the containers to fire or heat may result in their violent rupturing and rocketing.
Organothiophosphates, such as TETRAETHYL DITHIOPYROPHOSPHATE, are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides. SULFOTEP is incompatible with the following: Strong oxidizers, iron [Note: Corrosive to iron.] .
Toxic by ingestion, inhalation, and skin
absorption; cholinesterase inhibitor; use may be
restricted. Questionable carcinogen.
Non-systemic with contact and respiratory action. Acetylcholinesterase (AchE) inhibitor.
Poison by ingestion, skin contact, inhalation, intramuscular, intraperitoneal, subcutaneous, and intravenous routes. A cholinesterase inhbitor type of insecticide. When heated to decomposition it emits toxic fumes of POx and SOx. See also PARATHION.
Sulfotep is used in greenhouse fumigant formulations for control of aphids, spider mites; thrips, whiteflies, etc.
Soil. Cleavage of the molecule yields diethyl phosphate, monoethyl phosphate and
phosphoric acid (Hartley and Kidd, 1987).
Chemical/Physical. Emits toxic oxides of sulfur and phosphorus oxides when heated
to decomposition (Lewis, 1990).
Sulfotep and related compounds may be formed photochemically from
a number of phosphorodithioate and phosphorothioate insecticides
including azinphos-methyl, chlorpyrifos, malathion, methidathion and
phosalone (Abdelbagi and Gaston, 1998). Since sulfotep has a rather
high mammalian toxicity, this may be of some toxicological sigruficance.
Sulfotep is transformed in the environment via oxidative desulfuration
to the highly active anti-cholinesterase compounds monosulfotep and
tetraethyl pyrophosphate. It is deactivated by hydrolysis to O,O-diethyl
phosphorothioate and diethyl phosphate.
UN1704 (Sulfotep) Tetraethyl dithiopyrophosphate, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
Sulfotep is relatively slowly hydrolysed with DT50 values of 10.7,8.2 and
9.1 days at pH values 4,7 and 9 respectively (PM).
Sulfotep is formulated as fumigant. The
acute oral LD50 for rats is about 10 mg/kg. Inhalation
LC50 (4 h) for rats is about 0.05 mg/L air. NOEL (2 yr)
for rats is 10mg/kg diet (0.5mg/kg/d). ADI is 1 μg/kg
b.w. Sulfotep is activated by oxidative desulfuration to
tetraethyl monothiopyrophosphate and pyrophosphate in
the environment. Sulfotep administered to rats is quickly
eliminated. The major elimination product is diethyl
hydrogen phosphorothioate.
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine,bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Hydrolyzes very slowly in aqueous solution. Attacks some forms of plastic, rubber and coating. Corrosive to iron.
Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. In accordance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office. Incineration with added flammable solvent in furnace equipped with afterburner and alkaline scrubber.
