Dabcyl-GABA-PQGL-Glu(EDANS)-AK-NH2 (trifluoroacetate salt)

Dabcyl-GABA-PQGL-Glu(EDANS)-AK-NH2 is a fluorogenic substrate for matrix metalloproteinase-1 (MMP-1), MMP-2, MMP-3, and MMP-9.1 Upon enzymatic cleavage by MMP-1, MMP-2, MMP-3, or MMP-9 at the Gly-Leu site, EDANS is separated from the Dabcyl quencher and its fluorescence can be used to quantify MMP-1, MMP-2, MMP-3, and MMP-9 activity.1,2 EDANS displays excitation/emission maxima of 340/485 nm, respectively.WARNING This product is not for human or veterinary use.

[1] BOB BEEKMAN . Convenient fluorometric assay for matrix metalloproteinase activity and its application in biological media[J]. FEBS Letters, 1996, 390 2: Pages 221-225. DOI: 10.1016/0014-5793(96)00665-5
[2] FRANSISKA S. H. KRISMASTUTI  Nicolas H V  Stephanie Pace. Porous Silicon Resonant Microcavity Biosensor for Matrix Metalloproteinase Detection[J]. Advanced Functional Materials, 2014, 24 23: 3639-3650. DOI: 10.1002/adfm.201304053