Nω-Propyl-L-Arginine is a potent and selective inhibitor of neuronal nitric oxide synthase (nNOS). Nω-Propyl-L-Arginine is a competitive inhibitor of bovine nNOS having a Ki value of 57 nM. The Ki values for eNOS (bovine) and iNOS (murine) are 8.5 and 180 μM, respectively. Nω-propyl-L-Arginine therefore exhibits 3,000-fold and 150-fold selectivity for the neuronal isoform versus the inducible (murine) and endothelial (bovine) isoforms of NOS, respectively.
A highly selective competitive inhibitor and inactivator of all three isoforms of NOS.
Nω-Propyl-L-Arginine is a neuronal selective nitric oxide synthase inhibitor (1) and a highly selective competitive inhibitor and inactivator of all three isoforms of NOS (2,3).
Highly selective and potent inhibitor of nNOS (K i = 57 nM). Displays 3158-fold and 149-fold selectivity over iNOS and eNOS respectively. Hypotensive in vivo .
room temperature (desiccate)
[1] HENRY Q. ZHANG. Potent and Selective Inhibition of Neuronal Nitric Oxide Synthase by Nω-Propyl-l-arginine[J]. Journal of Medicinal Chemistry, 1997, 40 24: 3869-3870. DOI:
10.1021/jm970550g
