N-OMEGA-PROPYL-L-ARGININE

Description

N^ω-Propyl-L-Arginine is a potent and selective inhibitor of neuronal nitric oxide synthase (nNOS). N^ω-Propyl-L-Arginine is a competitive inhibitor of bovine nNOS having a K_i value of 57 nM. The K_i values for eNOS (bovine) and iNOS (murine) are 8.5 and 180 μM, respectively. N^ω-propyl-L-Arginine therefore exhibits 3,000-fold and 150-fold selectivity for the neuronal isoform versus the inducible (murine) and endothelial (bovine) isoforms of NOS, respectively.

Chemical Properties

Off-White Solid

Uses

A highly selective competitive inhibitor and inactivator of all three isoforms of NOS.

Uses

Nω-Propyl-L-Arginine is a neuronal selective nitric oxide synthase inhibitor (1) and a highly selective competitive inhibitor and inactivator of all three isoforms of NOS (2,3).

Biological Activity

Highly selective and potent inhibitor of nNOS (K i = 57 nM). Displays 3158-fold and 149-fold selectivity over iNOS and eNOS respectively. Hypotensive in vivo .

storage

room temperature (desiccate)