酪胺盐酸盐
酪胺盐酸盐 性质
熔点 | 271-274 °C(lit.) |
---|---|
沸点 | 269 °C |
密度 | 1.198±0.06 g/cm3(Predicted) |
储存条件 | 2-8°C |
溶解度 | DMF:50 mg/mL,澄清,无色 |
酸度系数(pKa) | 3.50±0.10(Predicted) |
形态 | 白色至灰白色冻干固体 |
颜色 | 白色到近乎白色 |
BRN | 2315783 |
序列 | N-Formyl-Met-Leu-Phe-OH |
CAS 数据库 | 59880-97-6(CAS DataBase Reference) |
酪胺盐酸盐 用途与合成方法
TNF-alpha
Binding of N-Formyl-Met-Leu-Phe to its specific cell surface receptor, N-formyl peptide receptor (FPR), triggers different cascades of biochemical events, eventually leading to cellular activation. FPR is a chemoattractant receptor belonging to the G protein-coupled receptor family. N-Formyl-Met-Leu-Phe promotes osteoblastic commitment and suppresses adipogenic commitment under osteoblastic differentiation conditions. N-Formyl-Met-Leu-Phe stimulates osteogenesis is associated with increased expression of osteogenic markers and mineralization. N-Formyl-Met-Leu-Phe inhibits expression of peroxisome proliferator-activated receptor-γ1. N-Formyl-Met-Leu-Phe-stimulated osteogenic differentiation is mediated via FPR1-phospholipase C/phospholipase D-Ca 2+ -calmodulin-dependent kinase II-ERK-CREB signaling pathways. N-Formyl-Met-Leu-Phe, a bacterial-derived peptide, induced proinflammatory cytokine gene expression in human peripheral blood monocytes. Bacterial products LPS and N-Formyl-Met-Leu-Phe synergistically induce inflammatory response via multiple signaling pathways. TLR4, IKKβ-IκBα, and NF-κB signaling pathways are involved in the synergistic induction of TNF-α via p65 nuclear translocation-dependent mechanisms.
N-Formyl-Met-Leu-Phe promotes bone formation in zebrafish and rabbits. Extensive skeletal development is evident at 5 dpf in over 80% of N-Formyl-Met-Leu-Phe-treated zebrafish. Treatment with N-Formyl-Met-Leu-Phe results in increased expression of Runx2. Bone marrow spaces are widely formed, and connective tissue covering bone is dense, like periosteum, in N-Formyl-Met-Leu-Phe-treated calvaria. N-Formyl-Met-Leu-Phe mediate release of calprotectin from PMN in vitro . It induces release of calprotectin from PMN in a dose dependent manner. A minimum of 10% of total PMN calprotectin is retained at concentrations of 0.1-10.0 nM of N-Formyl-Met-Leu-Phe.
纯度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
内毒素≤50EU/mg
氨基酸组成分析≤±10%
酪胺盐酸盐 价格(试剂级)
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024-11-08 | F1158 | N-甲酰基-L-甲硫氨酰-L-亮氨酰-L-苯丙氨酸 | 59880-97-6 | 25mg | 995 |
2024-11-08 | F1158 | N-甲酰基-L-甲硫氨酰-L-亮氨酰-L-苯丙氨酸 | 59880-97-6 | 100mg | 2390 |