59880-97-6
基本信息
酪胺盐酸盐
N-甲酰-L-甲硫氨酰-L-白氨酰-L苯丙氨酸
2-(4-HYDROXYPHENYL)ETHYLAMINE HYDROCHLORIDE
2-(4-HYDROXYPHENYL)ETHYLAMMONIUM CHLORIDE
4-(2-AMINOETHYL)PHENOL HYDROCHLORIDE
4-HYDROXYPHENETHYLAMINE HYDROCHLORIDE
4-HYDROXYPHENYLETHYLAMINE HCL
4-HYDROXYPHENYLETHYLAMINE HYDROCHLORIDE
P-(2-AMINOETHYL)PHENOL HYDROCHLORIDE
P-HYDROXYPHENETHYLAMINE HYDROCHLORIDE
TIMTEC-BB SBB003808
TYRAMINE
TYRAMINE HCL
TYRAMINE HYDROCHLORIDE
TYRAMINE MONOHYDROCHLORIDE
TYROSAMINE HCL
TYROSAMINE HYDROCHLORIDE
fMLF
fMLP (misnomer but widely used)
F-MET-LEU-PHE
TYRAMINE HCL(P)
物理化学性质
| 熔点 | 271-274 °C(lit.) |
| 熔点 | 271-274 °C(lit.) |
| 沸点 | 269 °C |
| 沸点 | 269 °C |
| 密度 | 1.198±0.06 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 储存条件 | 2-8°C |
| 溶解度 | DMF: 50 mg/mL, clear, colorless |
| 溶解度 | DMF：50 mg/mL，澄清，无色 |
| 酸度系数(pKa) | 3.50±0.10(Predicted) |
| 形态 | 白色至灰白色冻干固体 |
| 颜色 | 白色到近乎白色 |
| BRN | 2315783 |
| 序列 | N-Formyl-Met-Leu-Phe-OH |
| CAS 数据库 | 59880-97-6(CAS DataBase Reference) |
安全数据
| 危险品标志 | Xi |
| 危险类别码 | 36/37/38 |
| 危险类别码 | R36/37/38 |
| 安全说明 | 26-36-22 |
| 安全说明 | S26-S36-S22 |
| WGK Germany | 3 |
| WGK Germany | 3 |
| RTECS号 | SJ6050000 |
| F | 3-10 |
| 海关编码 | 2930.90.9250 |
知名试剂公司产品信息
酪胺盐酸盐价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/08/19 | F1158 | N-甲酰基-L-甲硫氨酰-L-亮氨酰-L-苯丙氨酸 N-Formyl-L-methionyl-L-leucyl-L-phenylalanine | 59880-97-6 | 25mg | 995元 |
| 2024/08/19 | F1158 | N-甲酰基-L-甲硫氨酰-L-亮氨酰-L-苯丙氨酸 N-Formyl-L-methionyl-L-leucyl-L-phenylalanine | 59880-97-6 | 100mg | 2390元 |
常见问题列表
TNF-alpha
Binding of N-Formyl-Met-Leu-Phe to its specific cell surface receptor, N-formyl peptide receptor (FPR), triggers different cascades of biochemical events, eventually leading to cellular activation. FPR is a chemoattractant receptor belonging to the G protein-coupled receptor family. N-Formyl-Met-Leu-Phe promotes osteoblastic commitment and suppresses adipogenic commitment under osteoblastic differentiation conditions. N-Formyl-Met-Leu-Phe stimulates osteogenesis is associated with increased expression of osteogenic markers and mineralization. N-Formyl-Met-Leu-Phe inhibits expression of peroxisome proliferator-activated receptor-γ1. N-Formyl-Met-Leu-Phe-stimulated osteogenic differentiation is mediated via FPR1-phospholipase C/phospholipase D-Ca 2+ -calmodulin-dependent kinase II-ERK-CREB signaling pathways. N-Formyl-Met-Leu-Phe, a bacterial-derived peptide, induced proinflammatory cytokine gene expression in human peripheral blood monocytes. Bacterial products LPS and N-Formyl-Met-Leu-Phe synergistically induce inflammatory response via multiple signaling pathways. TLR4, IKKβ-IκBα, and NF-κB signaling pathways are involved in the synergistic induction of TNF-α via p65 nuclear translocation-dependent mechanisms.
N-Formyl-Met-Leu-Phe promotes bone formation in zebrafish and rabbits. Extensive skeletal development is evident at 5 dpf in over 80% of N-Formyl-Met-Leu-Phe-treated zebrafish. Treatment with N-Formyl-Met-Leu-Phe results in increased expression of Runx2. Bone marrow spaces are widely formed, and connective tissue covering bone is dense, like periosteum, in N-Formyl-Met-Leu-Phe-treated calvaria. N-Formyl-Met-Leu-Phe mediate release of calprotectin from PMN in vitro . It induces release of calprotectin from PMN in a dose dependent manner. A minimum of 10% of total PMN calprotectin is retained at concentrations of 0.1-10.0 nM of N-Formyl-Met-Leu-Phe.