2-Bromo-4'-Benzyloxy-3'-nitroacetophenone

14347-05-8

43229-01-2

Step 2: 200 g of 4-benzyloxy-3-nitroacetophenone (Intermediate 1) was dissolved in 1000 mL of dichloromethane and 277 g of trimethylphenylammonium tribromide was added. The reaction mixture was heated to 300 °C and kept for 4 hours. After completion of the reaction, the residual liquid was poured into water, filtered, washed and dried to give 253 g of 3'-nitro-4'-benzyloxy-2-bromoacetophenone in 98% yield.