Reagent involved in reductive iodination for synthesis of [18F]FDOPA
Preparative Method of Diiodosilane: phenylsilane and iodine are mixed in a 1:1 molar ratio without solvent at -20 °C in the
presence of catalytic amounts of ethyl acetate; fractional distillation removes volatile side products (benzene
and HI) and affords the reagent in the form of a colorless oil.
Diiodosilane (DIS) is a strong, oxophilic Lewis acid, converts alcohols, ethers, and acetals to iodoalkanes; converts carboxylic
acid derivatives to acyl iodides; mild reducing agent.
Diiodosilane is sensitive to moisture; handle and store under nitrogen; stabilized by
metallic copper; refrigeration and absence of light recommended for storage over long periods of time.
