B014

Chemical Properties

Boiling point	513.5±50.0 °C(Predicted)
Density	1.211±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: soluble5mg/mL, clear (warmed)
form	powder
pka	3.84±0.10(Predicted)
color	white to beige

Send Inquriy

Animal Model:	Nude athymic mice, A549 xenografts^[1]
Dosage:	100 mg/kg alone or in combination with 25 mg/kg Erlotinib (HY-50896)
Administration:	i.v./i.p., daily for 25 days
Result:	The combined treatment resulted in more significant tumor growth delay (28%) compared with treatment alone (7%). The combination produced significantly higher anti-tumor activity. The growth of A549 cancer cell xenografts was suppressed by 11, 21 and 49% (tumor growth inhibition) after treatment with MPT0B014, Erlotinib and MPT0B014 plus Erlotinib, respectively.