PI3-Kinase α Inhibitor 2

PI3-Kinase α (PI3Kα) inhibitor 2 is an inhibitor of PI3K p110α (IC₅₀ = 2 nM in an enzyme assay). It is selective for p110α over p110β, p110γ, and PI3K C2β (IC₅₀s = 16, 660, and 220 nM, respectively). It also inhibits mammalian target of rapamycin (mTOR; IC₅₀ = 49 nM). PI3Kα inhibitor 2 inhibits proliferation in A375 melanoma cells with an IC₅₀ value of 0.58 μM.

ChEBI: PI3-Kinase alpha Inhibitor 2 is an organonitrogen heterocyclic compound, an organosulfur heterocyclic compound and an organic heterobicyclic compound.