m-PEG12-acid is a PEG linker containing a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media.
MeO-PEG(12)-COOH is used in the preparation of fishbone-like polymer brushes with potential applications in the production of smart materials and biosensors.
MPEG11-CH2CH2COOH (CAS 2135793-73-4) is a high-purity, monodisperse PEG-based PROTAC linker. It has a molecular weight of 588.68 and appears as a colourless to pale yellow viscous liquid or a low-melting-point waxy solid at room temperature. This substance is also known as m-PEG12-acid, mPEG11-propionic acid and mPEG11-COOH. It should be noted that m-PEG12-acid usually refers to a polydisperse polymer with CAS number 125220-94-2. Care should be taken to distinguish between the two when purchasing.
