m-PEG12-Mal is a PEG linker containing a maleimide group. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. The hydrophilic PEG spacer increases solubility in aqueous media.
Mal-PEG-OH (MW 5000) can be used as a macroinitiator to obtain amphiphilic diblock copolymers by ring-opening polymerization of LA. Nanoparticles prepared using amphiphilic block copolymers can form active drug delivery systems. Nanoparticles encapsulate Triptolide (HY-32735), which can avoid the disadvantage of Triptolide’s poor water solubility and reduce its toxicity.
reagent type: chemical modification reagent
reagent type: cross-linking reagent
reactivity: sulfhydryl reactive
reagent type: linker
reactivity: thiol reactive
[1] Chen XY, et al. The potential of follicle-stimulating hormone peptide-modified triptolide-loaded nanoparticles to induce a mouse model of premature ovarian insufficiency. Int J Nanomedicine. 2015 Apr 7;10:2765-74. DOI:
10.2147/IJN.S72593
