TCS21311; TCS-21311
TCS21311; TCS-21311 性质
| 沸点 | 793.0±60.0 °C(Predicted) |
|---|---|
| 密度 | 1.436±0.06 g/cm3(Predicted) |
| 储存条件 | +2C to +8C |
| 溶解度 | <52.65mg/ml，溶于 DMSO |
| 形态 | 黄色固体 |
| 酸度系数(pKa) | 7.91±0.60(Predicted) |
| 颜色 | 白色至黄色 |
| InChIKey | CLGRAWDGLMENOD-UHFFFAOYSA-N |
| SMILES | O=C1NC(C(C2=CNC3=C2C=CC=C3)=C1C4=CC(N5CCN(C(C(C)(C)O)=O)CC5)=CC=C4C(F)(F)F)=O |
TCS21311; TCS-21311 用途与合成方法
|
JAK3 8 nM (IC 50 ) |
JAK2 2.55 μM (IC 50 ) |
JAK1 1.017 μM (IC 50 ) |
PKCα 13 nM (IC 50 ) |
PKCθ 68 nM (IC 50 ) |
GSK-3β 3 nM (IC 50 ) |
TCS 21311 (NIBR3049) exhibits IC 50 values of 1.017, 2.550 and 8.055 μM for JAK1, JAK2 and TYK2, respectively in a enzymatic Jak assay. TCS 21311 (NIBR3049) shows moderate activity in this cellular assay (IC 50 =689 nM, Jurkat cells), which is in good agreement with its enzymatic Pkc activity.
TCS21311; TCS-21311 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025-12-22 | HY-108264 | TCS21311; TCS-21311 | 1260181-14-3 | 1mg | 550 |
| 2025-12-22 | HY-108264 | TCS21311; TCS-21311 | 1260181-14-3 | 5mg | 1800 |
