1H-PYRAZOLE, 1-[2-(1-PYRROLIDINYL)ETHYL]-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-
1H-PYRAZOLE, 1-[2-(1-PYRROLIDINYL)ETHYL]-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-
![1H-PYRAZOLE, 1-[2-(1-PYRROLIDINYL)ETHYL]-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)- 结构式](https://img.chemicalbook.com/CAS/GIF/1000802-52-7.gif)
1H-PYRAZOLE, 1-[2-(1-PYRROLIDINYL)ETHYL]-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)- 性质
| 沸点 | 416.9±25.0 °C(Predicted) |
|---|---|
| 密度 | 1.11±0.1 g/cm3(Predicted) |
| 储存条件 | Inert atmosphere,Store in freezer, under -20°C |
| 酸度系数(pKa) | 9.83±0.20(Predicted) |
| 外观 | 白色至灰白色固体 |
1H-PYRAZOLE, 1-[2-(1-PYRROLIDINYL)ETHYL]-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)- 用途与合成方法
269410-08-4
7250-67-1
![1H-PYRAZOLE, 1-[2-(1-PYRROLIDINYL)ETHYL]-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-](/CAS/GIF/1000802-52-7.gif)
1000802-52-7
以4-吡唑硼酸频哪醇酯（1.7g，8.8mmol）和N-(2-氯乙基)吡咯烷盐酸盐（1.48g，8.70mmol）为原料，在碳酸钾（3.7g，27.00mmol）存在下，于DMF（15mL）中80℃搅拌反应6小时。反应完成后，将反应混合物用水（50mL）稀释，并用二氯甲烷（50mL×3）萃取。合并有机层，用饱和氯化钠水溶液（15mL）洗涤，无水硫酸钠干燥，减压浓缩。通过硅胶柱色谱法纯化残余物，以二氯甲烷/乙酸乙酯（v/v，20/1）为洗脱剂，得到浅黄色液体产物1-[2-(1-吡咯烷)乙基]-4-(4,4,5,5-四甲基-1,3,2-二噁硼烷-2-基)-1H-吡唑（1.27g，收率50.10%）。质谱（ESI，正离子模式）m/z：292.10 [M + 1]+。
参考文献：
[1] Patent: WO2016/615, 2016, A1. Location in patent: Paragraph 00719
[2] Patent: US2010/273796, 2010, A1. Location in patent: Page/Page column 20-21
[3] Patent: US2011/34474, 2011, A1. Location in patent: Page/Page column 22
[4] Patent: US2011/71153, 2011, A1. Location in patent: Page/Page column 21
[5] Patent: US2011/92498, 2011, A1. Location in patent: Page/Page column 20-21
1H-PYRAZOLE, 1-[2-(1-PYRROLIDINYL)ETHYL]-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)- 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-09-15 | XW02100080252704 | 1-[2-(1-吡咯烷)乙基]-4-(4,4,5,5-四甲基-1,3,2-二噁硼烷-2-基)-1H-吡唑 | 1000802-52-7 | 5G | 7241 |
| 2026-09-15 | XW02100080252703 | 1-[2-(1-吡咯烷)乙基]-4-(4,4,5,5-四甲基-1,3,2-二噁硼烷-2-基)-1H-吡唑 | 1000802-52-7 | 1G | 1714 |
