DL-Propargylglycine

Hydrogen sulphide (H₂S), a naturally occurring gasotransmitter, is a potent vasodilator and pro-inflammatory mediator. DL-Propargyl glycine (PAG) is an irreversible inhibitor of the H₂S synthesizing enzyme cystathionine-γ-lyase (CSE). PAG blocks H₂S synthesis activity in rat liver preparations with an IC₅₀ value of 55 μM and abolishes the rise in plasma H₂S in anaesthetized rats induced with hemorrhagic shock. At concentrations ranging from 25-100 mg/kg, PAG can reduce H₂S-associated inflammation in rodent models of pancreatitis, oedema, and endotoxemia.

DL-Propargylglycine Hydrochloride is used in preparation of tert-Butoxycarbonyl Azide.

[1] MADHAV BHATIA. Pro-inflammatory effects of hydrogen sulphide on substance P in caerulein-induced acute pancreatitis[J]. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2007, 12 2: 580-590. DOI: 10.1111/j.1582-4934.2007.00131.x
[2] MADHAV BHATIA. Hydrogen sulphide is a mediator of carrageenan-induced hindpaw oedema in the rat[J]. British Journal of Pharmacology, 2009, 145 2: 141-144. DOI: 10.1038/sj.bjp.0706186
[3] MARIKA COLLIN. Inhibition of endogenous hydrogen sulfide formation reduces the organ injury caused by endotoxemia[J]. British Journal of Pharmacology, 2009, 146 4: 498-505. DOI: 10.1038/sj.bjp.0706367