Description
Hydrogen sulphide (H
2S), a naturally occurring gasotransmitter, is a potent vasodilator and pro-
inflammatory mediator. DL-
Propargyl glycine (PAG) is an irreversible inhibitor of the H
2S synthesizing enzyme cystathionine-
γ-
lyase (CSE). PAG blocks H
2S synthesis activity in rat liver preparations with an IC
50 value of 55 μM and abolishes the rise in plasma H
2S in anaesthetized rats induced with hemorrhagic shock. At concentrations ranging from 25-
100 mg/kg, PAG can reduce H
2S-
associated inflammation in rodent models of pancreatitis, oedema, and endotoxemia.
